23 studies on Orexin a curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This ambitious cohort study is crucial for advancing our understanding of chronic hypersomnolence by providing a rich, integrated dataset. The collected data will be instrumental in identifying novel biomarkers for di…
The findings from this study, once published, could significantly advance our understanding of GLP-1 agonists beyond weight loss, specifically in treating binge eating disorder. If Liraglutide proves effective, it cou…
Understanding the direct biological links between chronic insomnia and dementia biomarkers could revolutionize early detection and intervention strategies. If specific CSF markers are reliably associated with chronic …
This Phase 2 long-term extension study is crucial for understanding the sustained impact of ORX750 on chronic sleep disorders, moving beyond short-term efficacy data. Long-term safety and sustained efficacy are paramo…
This research could provide a novel, non-invasive treatment option for the challenging comorbidity of depression in narcolepsy patients. If successful, iTBS could offer a well-tolerated alternative or adjunct to exist…
The development of effective, comprehensive intervention techniques for adolescent depression is paramount, given the high prevalence and profound impact of this condition on young lives and public health systems. Thi…
These promising Phase 2 results suggest that ALKS 2680 could offer a novel, effective, and well-tolerated treatment option for Narcolepsy Type 1, directly addressing both excessive daytime sleepiness and cataplexy. Th…
This study is crucial because it could establish continuous glucose monitoring (CGM) as a superior standard of care for managing hyperglycemia in hospitalized patients, potentially reducing inflammation and improving …
If successful, this study could validate PS150 as a novel, non-pharmacological intervention for insomnia, offering a natural alternative to traditional sleep aids. The findings could highlight the critical role of the…
This research significantly advances our understanding of the brain's hedonic circuitry, pinpointing the olfactory tubercle as a critical "hedonic hotspot" for taste pleasure. The identification of specific neurochemi…
The review identified significant neurobiological overlaps between Anorexia Nervosa (AN) and addiction-like features, particularly within the dopaminergic, endocannabinoid, and orexinergic systems. Dysregulation in th…
This study provides crucial objective evidence linking persistent sleep disturbances after mTBI to specific hormonal imbalances, particularly dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and melatoni…
This research highlights a novel neuroprotective role for Orexin-A beyond its established functions in sleep and appetite, specifically in modulating neuroinflammatory responses. The finding that Orexin-A can inhibit …
This research highlights a fundamental, stable neural mechanism involving orexin-A neurons that underlies the acute stress response, operating independently of the more variable hormonal profiles across different life…
Understanding the genetic and clinical heterogeneity of narcolepsy across diverse ethnic groups is crucial for improving diagnosis and personalized treatment strategies. This research could lead to the identification …
Shift-Work Sleep Disorder and associated stress are prevalent and serious issues, particularly among healthcare workers, impacting both personal well-being and potentially patient safety. Non-pharmacological intervent…
This pilot study provides compelling preliminary evidence that liraglutide could offer a novel therapeutic approach for sleep apnea in non-diabetic individuals, potentially independent of its weight-loss effects. The …
The PubChem profile unequivocally identifies Orexin A through its unique Compound ID (CID): 56842143, a standard identifier in chemical databases. It precisely outlines the peptide's complex molecular formula as C152H…