87 studies on Orexin a curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
Bottom line: TitrateLab currently curates 87 dated studies on Orexin a. The source summaries below describe published research; they do not establish product quality, safety, or clinical suitability.
Efficacy and safety of 6x/day and 10x/day accelerated TMS vs. sham stimulation for **Treatment-Resistant Depression** are being compared.
**Improving sleep quality and reducing delirium in cardiac ICU patients could significantly enhance recovery and long-term outcomes.** If **suvorexant** proves effective, it could offer a targeted, non-sedating pharma…
Understanding the intricate role of **orexin-A** in linking feeding, energy balance, and emotional states offers crucial insights for individuals struggling with **obesity-anxiety comorbidity**. **Targeting the orexin…
An observational study investigated if auto-induction of transdermal nicotine replacement therapy (NRT) can serve as a non-invasive surrogate for nicotinic acetylcholine receptor upregulation.
**BF2.649 represents a promising new therapeutic avenue for narcolepsy**, particularly for managing **Excessive Daytime Sleepiness (EDS)**. By targeting the `H3R` as an inverse agonist, it offers a distinct mechanism …
Understanding the precise impact of sustained **sleep restriction** is crucial for public health, informing guidelines for sleep hygiene and occupational safety. For individuals, this research will underscore the impo…
Understanding the **ventral tegmental area (VTA)**'s intricate role provides a crucial foundation for developing more targeted and effective interventions for **addiction** and related psychiatric disorders. **This co…
This research provides compelling preclinical evidence that targeting the orexin system could be a crucial strategy for preventing **stress-induced alcohol addiction** and relapse, especially in adolescents. For indiv…
If successful, this trial could establish a foundation for **suvorexant** as a novel adjunctive therapy for **Major Depressive Disorder** patients with elevated suicide risk, potentially offering a new strategy beyond…
A study will observe how new add-on anti-diabetic drugs, including Liraglutide, affect inflammation and energy homeostasis in Type 2 Diabetes outpatients.
If the aims of this pilot trial are met, **Suvorexant** could emerge as a valuable adjunctive therapy for **substance use disorder (SUD)** patients struggling with insomnia and craving. **Improving sleep quality and r…
Daridorexant will be used in healthy volunteers to clarify orexin's role in emotional processing, aversive learning, and executive function, relevant to depression and anxiety.
Plasma Orexin A levels and `pre-pro-orexin` gene expression are associated with **ADHD** symptoms and neurocognitive deficits, suggesting orexin system involvement.
If the hypothesis is confirmed, this research could fundamentally shift recommendations for **metabolic health**, moving beyond just "what" and "how much" to include "when." **Optimizing sleep and meal timing** could …
A prospective study will evaluate a millimeter-wave radar system's feasibility for non-contact **Narcolepsy Type 1** diagnosis against PSG/MSLT in **40** patients.
Prior research found gut microbiota dysbiosis in **Type 1 Narcolepsy** patients, leading to a hypothesis that bacterial translocation drives autoimmune hypocretin neuron destruction.
This study **validates the unilateral intrastriatal 6-OHDA mouse model** as a suitable tool for recapitulating progressive orexin A neuron loss seen in human Parkinson's disease. This is a significant step for researc…
This study provides a crucial translational model for investigating the complex interplay between **α-synuclein** pathology and circadian rhythm disruption in **Parkinson's disease**. For researchers and biohackers in…
These findings provide critical insights into the pathophysiology of **CLN3 disease**, highlighting specific biomarkers that can significantly improve disease monitoring. **Reduced CSF orexin-A and elevated NfL offer …
This research provides crucial insights into the complex neural circuitry of pain, specifically highlighting the **dentate gyrus** as a key site for **orexinergic** and **opioidergic** interaction. For those exploring…
This study offers crucial preliminary evidence that **plasma Orexin-A levels could serve as a novel biomarker for postpartum depression**, potentially enabling earlier and more objective diagnosis beyond current sympt…
Suvorexant is proposed for **Restless Legs Syndrome** treatment, aiming to avoid augmentation risks associated with current dopamine agonists.
A randomized study aims to assess how anesthetic choice, including dexmedetomidine, impacts glymphatic function, neuroinflammation, and postoperative cognitive dysfunction in VP-shunt patients.
A multidisciplinary weight loss program at AUB-MC evaluates feasibility and efficacy of an innovative dietary intervention, exercise, and behavioral therapy for weight management.
This study investigates the functional role of the opioidergic system within the ventral tegmental area (VTA) and dentate gyrus in modulating persistent inflammatory pain in rats.
This study provides a robust mechanistic explanation for **Spinosin**'s traditional use as a hypnotic, identifying the `adenosine A2A receptor` as its direct molecular target. For individuals seeking natural sleep aid…
Daridorexant, an orexin blocker, is proposed as a smoking cessation therapy to improve sleep and alertness in smokers, addressing key relapse risks.
Circadian-related **melatonin** and **serotonin** levels influence susceptibility to **cisplatin**-induced hearing loss through the `NOS3–NO` pathway.
Understanding this interconnected regulatory network is vital for **improving therapies** for **obesity**, **anorexia nervosa**, and **binge-eating disorder**. The identification of novel players and the blurring of h…
This comparative systematic review provides crucial insights for clinicians and patients navigating treatment options for **postmenopausal osteoporosis**. Understanding the relative benefits and risks of **romosozumab…
This review fundamentally shifts our understanding of the **claustrum's functional integration**, moving beyond its traditional role in consciousness to highlight its direct involvement in memory and sleep regulation …
This study suggests a novel therapeutic avenue for **diabetic ocular complications** by repurposing **Suvorexant**, a drug already approved for insomnia. The findings indicate that targeting the orexin system could of…
**If successful, this study could establish suvorexant as a valuable adjunctive therapy for Veterans with PTSD undergoing exposure-based interventions.** Improving sleep quality post-therapy may enhance the benefits o…
Understanding the specific manifestations of **narcolepsy** in children is crucial for improving diagnosis and developing age-appropriate management strategies. This study's future findings could provide clinicians wi…
**If this study demonstrates efficacy, suvorexant could become a valuable, accessible, and safe adjunct therapy for Veterans with PTSD**, particularly those experiencing comorbid insomnia and impaired fear extinction.…
This study aims to explore the roles of ghrelin, leptin, adiponectin, NPY, orexin A, IGF-1, IGFBP-1, IGFBP-3, and CRH in the nutritional status of children with feeding difficulties.
This study identifies **Orexin B** as a promising therapeutic candidate for **cerebral aneurysm** prevention or treatment, offering a novel anti-inflammatory mechanism via the `OX2R`/`SP-1` pathway. The finding that O…
If successful, this trial could validate **suvorexant** as a novel, non-addictive pharmacological option for **alcohol use disorder**, particularly for individuals whose drinking is exacerbated by stress or co-occurri…
This comparative effectiveness trial is crucial for advancing the management of **menopause-related insomnia**, offering direct insights into which commonly used therapies are most effective and safe. For clinicians, …
A delayed arousal response to obstructive sleep apnea events is identified as a significant predictor of increased mortality risk.
This finding suggests a significant paradigm shift for managing **cancer-related fatigue** (CRF), a major unmet need in oncology. **Optimizing chemotherapy timing** could dramatically improve patient quality of life d…
A hypothalamic-brainstem activity sequence drives arousal fluctuations during daytime drowsiness, revealing neural mechanisms of alertness.
If this trial demonstrates positive results, **Suvorexant** could become a valuable and targeted therapeutic option for managing **post-operative sleep disturbance**, potentially improving recovery trajectories and pa…
This study's findings could provide **evidence-based guidance for snack choices** aimed at improving satiety and managing caloric intake. For individuals focused on weight management or optimizing their diet, understa…
Improving sleep quality during **opioid withdrawal** could significantly enhance patient comfort and reduce the likelihood of relapse, a major challenge in **OUD** treatment. If **suvorexant** proves effective, it cou…
If the proposed findings are realized, this research could fundamentally shift the approach to treating **cocaine use disorder**. **Identifying a novel mechanism like orexin antagonism for addiction could lead to the …
A clinical trial will investigate if `Limosilactobacillus fermentum PS150` (HT-PS150) improves sleep indicators in 90 human subjects over 8 weeks.
This planned research is critical for refining **personalized treatment strategies** for obese patients on Semaglutide. If specific dietary patterns, such as the **Mediterranean diet** or **HP/LC diet**, demonstrate s…
If this Phase IV trial confirms the efficacy of **suvorexant** in preventing delirium and improving sleep in hospitalized cancer patients, it would represent a significant advancement in supportive oncology care. **Th…
The establishment of the **QUVIVIQ Pregnancy Registry** is a critical step towards providing much-needed safety information for **Daridorexant** use during pregnancy. Currently, data on the effects of newer hypnotics …
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